Laboratory of Chemistry of Noninfectious Immunity
Head of the Lab:
CHERNIKOV Oleg, Ph.D.
Tel. +7 (423) 231-07-19, chernikov@piboc.dvo.ru
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LUKYANOV Pavel
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CHIKALOVETS Irina
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MOLCHANOVA Valentina
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KOKOULIN Maksim
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ZAKHARKINA Lidia
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FILSHTEIN Alina
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KOBELEV Stanislav
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BUSAROVA Natalia
| MIZGINA Tatyana
Ph.D. Student |
Marine polysaccharide recently attracted attention because they are not toxic and reveal interesting biological properties (immunomodulatory, anti-inflammatory, radio-protective, antiviral, antimicrobial, anti-tumor, wound-healing and etc.). They can find application in medical practice, food and cosmetic industries.
Both microorganisms and macrophitic algae are the important component of marine ecosystems and possess a wide spectrum of physiological adaptable mechanisms.
The chemical structure of the carbohydrate moiety of the marine gram-negative bacteria lipopolysachharides is highly diverse and includes an ever-extending number of rare and unusual monosaccharides and non-carbohydrate substituents. A comparative study of lipopolysachharides primary structure is important for understanding the chemical modifications of the cell envelope to reinforce the external membrane and to ensure their survival.
Our Lab mainly focuses on isolation of the lectins and polysaccharides, lipopolysaccharides, exopolysaccharides from marine invertebrates and bacteria. We investigate the chemical and biological properties. Study the role in marine organisms and bacteria.
The main goals:
Structure and function of biological macromolecules (polysaccharides, lipopolysaccharides, exopolysaccharides, lectins and carbohydrate-protein complexes) and investigation of their biological properties. Molecular bases of immunity.